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Chemical structure of Didesmethylrocaglamide

GC39808

Didesmethylrocaglamide

Also known as (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide

Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor· Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM· Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells· Antitumor activity

ChemicalCAS177262-30-5MW477.51FormulaC27H27NO7
CAS number
177262-30-5
Molecular weight
477.51
Formula
C27H27NO7
Solubility
DMSO： 100 mg/mL (209·42 mM)
InChIKey
RMNPQEWLGQURNX-PXIJUOARSA-N
Catalogue number
GC39808
Brand
GLPBIO
Computed properties PubChem CID 397614 · XLogP 2.2 · TPSA 120 Ų · H-bond donors 3
XLogP
2.2
TPSA
120 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
35

SMILES COC1=CC=C(C=C1)[C@]23[C@@H]([C@H]([C@H]([C@]2(C4=C(O3)C=C(C=C4OC)OC)O)O)C(=O)N)C5=CC=CC=C5

Computed descriptors from PubChem (CID 397614), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Lead time
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