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Chemical structure of 2BAct

GC39800

2BAct

Also known as N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]-1-bicyclo[1.1.1]pentanyl]-5-(difluoromethyl)pyrazine-2-carboxamide

2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM

ChemicalCAS2143542-28-1MW440.8FormulaC19H16ClF3N4O3
CAS number
2143542-28-1
Molecular weight
440.8
Formula
C19H16ClF3N4O3
Solubility
Soluble in DMSO
InChIKey
HYQJXXCYOYRNMP-UHFFFAOYSA-N
Catalogue number
GC39800
Brand
GLPBIO
Computed properties PubChem CID 132091799 · XLogP 2.2 · TPSA 93.2 Ų · H-bond donors 2
XLogP
2.2
TPSA
93.2 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
30

SMILES C1C2(CC1(C2)NC(=O)C3=NC=C(N=C3)C(F)F)NC(=O)COC4=CC(=C(C=C4)Cl)F

Computed descriptors from PubChem (CID 132091799), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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