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Chemical structure of AMY-101

GC39697

AMY-101

Also known as 2-[(4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-34-[[(2S,3S)-2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]-methylcarbamoyl]-25-(3-amino-3-oxopropyl)-7-(3-carbamimidamidopropyl)-10-(1H-imidazol-5-ylmethyl)-19-(1H-indol-3-ylmethyl)-13,17-dimethyl-28-[(1-methylindol-3-yl)methyl]-6,9,12,15,18,21,24,27,30,33-decaoxo-31-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decazacyclopentatriacont-22-yl]acetic acid

AMY-101 (Cp40) is the efficient inhibitor of the central complement component C3, with sub-nanomolar affinity for C3 (KD= 0·5nmol/L)

ChemicalCAS1427001-89-5MW1789.11FormulaC83H117N23O18S2
CAS number
1427001-89-5
Molecular weight
1789.11
Formula
C83H117N23O18S2
Solubility
100mg/mL in Water
InChIKey
MUSGYEMSJUFFHT-UWABRSFTSA-N
Catalogue number
GC39697
Brand
GLPBIO
Computed properties PubChem CID 131634231 · XLogP -2.1 · TPSA 692 Ų · H-bond donors 21
XLogP
-2.1
TPSA
692 Ų
H-bond donors
21
H-bond acceptors
23
Rotatable bonds
30
Heavy atoms
126

SMILES CC[C@H](C)[C@@H](C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)CC2=CN(C3=CC=CC=C32)C)CCC(=O)N)CC(=O)O)CC4=CNC5=CC=CC=C54)C)C)CC6=CN=CN6)CCCNC(=N)N)C(=O)N(C)[C@@H]([C@@H](C)CC)C(=O)N)NC(=O)[C@@H](CC7=CC=C(C=C7)O)N

Computed descriptors from PubChem (CID 131634231), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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