Loading...
Chemical structure of Tyk2-IN-9

GC39644

Tyk2-IN-9

Also known as 3-(cyanomethyl)-3-[4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]cyclobutane-1-carbonitrile

Tyk2-IN-9 (Compound 26) is a selective Tyk-2 inhibitor with IC50s of 0·076 and 1·8 nM for TYK2-JH2 and JAK1-JH2, respectively

ChemicalCAS2127109-85-5MW383.41FormulaC20H17N9
CAS number
2127109-85-5
Molecular weight
383.41
Formula
C20H17N9
Solubility
DMSO： 3·33 mg/mL (8·69 mM; ultrasonic and adjust pH to 4 with HCl)
InChIKey
XPLZTJWZDBFWDE-UHFFFAOYSA-N
Catalogue number
GC39644
Brand
GLPBIO
Computed properties PubChem CID 130339268 · XLogP -0.4 · TPSA 113 Ų · H-bond donors 0
XLogP
-0.4
TPSA
113 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
29

SMILES CN1C=C(C=N1)C2=CN3C(=CC=N3)C(=N2)C4=CN(N=C4)C5(CC(C5)C#N)CC#N

Computed descriptors from PubChem (CID 130339268), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.