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Chemical structure of UNC6852

GC39588

UNC6852

Also known as (2S,4R)-1-[(2S)-2-[4-[[4-[5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl]benzoyl]amino]butanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC50 of 247 nM for EED

ChemicalCAS2688842-08-0MW832.97FormulaC43H48N10O6S
CAS number
2688842-08-0
Molecular weight
832.97
Formula
C43H48N10O6S
Solubility
DMSO： 100 mg/mL (120·05 mM)
InChIKey
PPNNFXIBKLCMTI-WXEAQWFJSA-N
Catalogue number
GC39588
Brand
GLPBIO
Computed properties PubChem CID 146014466 · XLogP 4.7 · TPSA 237 Ų · H-bond donors 5
XLogP
4.7
TPSA
237 Ų
H-bond donors
5
H-bond acceptors
12
Rotatable bonds
16
Heavy atoms
60

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCNC(=O)C4=CC=C(C=C4)C5=CN=C(N6C5=NN=C6)NCC7=CC=CO7)O

Computed descriptors from PubChem (CID 146014466), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.