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Chemical structure of CH6953755

GC39557

CH6953755

Also known as N-[2-[5-amino-1-[6-(2,6-difluorophenoxy)-4-methyl-3-pyridinyl]pyrazole-4-carbonyl]-5-methyl-1H-indol-6-yl]methanesulfonamide

CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC50 of 1·8 nM· CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo

ChemicalCAS2055918-71-1MW552.55FormulaC26H22F2N6O4S
CAS number
2055918-71-1
Molecular weight
552.55
Formula
C26H22F2N6O4S
Solubility
DMSO： 125 mg/mL (226·22 mM)
InChIKey
YVXUHNOWRKWXSJ-UHFFFAOYSA-N
Catalogue number
GC39557
Brand
GLPBIO
Computed properties PubChem CID 124149825 · XLogP 4.6 · TPSA 153 Ų · H-bond donors 3
XLogP
4.6
TPSA
153 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
7
Heavy atoms
39

SMILES CC1=CC2=C(C=C1NS(=O)(=O)C)NC(=C2)C(=O)C3=C(N(N=C3)C4=CN=C(C=C4C)OC5=C(C=CC=C5F)F)N

Computed descriptors from PubChem (CID 124149825), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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