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Chemical structure of Syrosingopine

GC39536

Syrosingopine

Also known as methyl (1R,15S,17R,18R,19S,20S)-17-(4-ethoxycarbonyloxy-3,5-dimethoxybenzoyl)oxy-6,18-dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate

Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin

ChemicalCAS84-36-6MW666.71FormulaC35H42N2O11
CAS number
84-36-6
Molecular weight
666.71
Formula
C35H42N2O11
Solubility
DMSO: 62·5 mg/mL (93·74 mM)
InChIKey
ZCDNRPPFBQDQHR-SSYATKPKSA-N
Catalogue number
GC39536
Brand
GLPBIO
Computed properties PubChem CID 6769 · XLogP 4.6 · TPSA 144 Ų · H-bond donors 1
XLogP
4.6
TPSA
144 Ų
H-bond donors
1
H-bond acceptors
12
Rotatable bonds
13
Heavy atoms
48

SMILES CCOC(=O)OC1=C(C=C(C=C1OC)C(=O)O[C@@H]2C[C@@H]3CN4CCC5=C([C@H]4C[C@@H]3[C@@H]([C@H]2OC)C(=O)OC)NC6=C5C=CC(=C6)OC)OC

Computed descriptors from PubChem (CID 6769), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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