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Chemical structure of NL-1

GC39411

NL-1

Also known as 5-[(3,5-ditert-butyl-4-hydroxyphenyl)methyl]-1,3-thiazolidine-2,4-dione

NL-1 is a mitoNEET inhibitor with antileukemic effect· NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47·35 ?M and 56·26 ?M, respectively· NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway

ChemicalCAS188532-26-5MW335.46FormulaC18H25NO3S
CAS number
188532-26-5
Molecular weight
335.46
Formula
C18H25NO3S
Solubility
DMSO： 250 mg/mL (745·25 mM)
InChIKey
QDYYSPGKYXWGSL-UHFFFAOYSA-N
Catalogue number
GC39411
Brand
GLPBIO
Computed properties PubChem CID 9819104 · XLogP 5 · TPSA 91.7 Ų · H-bond donors 2
XLogP
5
TPSA
91.7 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
23

SMILES CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CC2C(=O)NC(=O)S2

Computed descriptors from PubChem (CID 9819104), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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