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Chemical structure of GSK2798745

GC39387

GSK2798745

Also known as 3-[[(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl]methyl]benzimidazole-5-carbonitrile

GSK2798745 is a potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1·8 and 1·6 nM for hTRPV4 and rTRPV4, respectively

ChemicalCAS1419609-94-1MW460.53FormulaC25H28N6O3
CAS number
1419609-94-1
Molecular weight
460.53
Formula
C25H28N6O3
Solubility
DMSO： 250 mg/mL (542·85 mM)
InChIKey
URCMKDJBULWNAI-DQEYMECFSA-N
Catalogue number
GC39387
Brand
GLPBIO
Computed properties PubChem CID 71227359 · XLogP 2 · TPSA 117 Ų · H-bond donors 1
XLogP
2
TPSA
117 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
34

SMILES C[C@@]1(CCC[C@]2(C1)CN(C(=O)O2)C3=NC=C(N=C3)C(C)(C)O)CN4C=NC5=C4C=C(C=C5)C#N

Computed descriptors from PubChem (CID 71227359), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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