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Chemical structure of Atabecestat

GC39341

Atabecestat

Also known as N-[3-[(4S)-2-amino-4-methyl-1,3-thiazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide

Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction

ChemicalCAS1200493-78-2MW367.4FormulaC18H14FN5OS
CAS number
1200493-78-2
Molecular weight
367.4
Formula
C18H14FN5OS
Solubility
DMSO： 250 mg/mL (680·46 mM)
InChIKey
VLLFGVHGKLDDLW-SFHVURJKSA-N
Catalogue number
GC39341
Brand
GLPBIO
Computed properties PubChem CID 68254185 · XLogP 2 · TPSA 129 Ų · H-bond donors 2
XLogP
2
TPSA
129 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
26

SMILES C[C@]1(C=CSC(=N1)N)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F

Computed descriptors from PubChem (CID 68254185), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.