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Chemical structure of YQ128

GC39311

YQ128

Also known as N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-(prop-2-ynylsulfamoyl)phenyl]ethyl]-2-thiophen-3-ylacetamide

YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC50 of 0·30 ?M

ChemicalCAS2454246-18-3MW545.11FormulaC27H29ClN2O4S2
CAS number
2454246-18-3
Molecular weight
545.11
Formula
C27H29ClN2O4S2
Solubility
DMSO： 250 mg/mL (458·62 mM)
InChIKey
SFPYRFRNYALLHS-UHFFFAOYSA-N
Catalogue number
GC39311
Brand
GLPBIO
Computed properties PubChem CID 139600339 · XLogP 5 · TPSA 112 Ų · H-bond donors 1
XLogP
5
TPSA
112 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
13
Heavy atoms
36

SMILES CCCOC1=C(C=C(C=C1)Cl)CN(CCC2=CC=C(C=C2)S(=O)(=O)NCC#C)C(=O)CC3=CSC=C3

Computed descriptors from PubChem (CID 139600339), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.