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Chemical structure of MC-GGFG-DX8951

GC39309

MC-GGFG-DX8951

Also known as 6-(2,5-dioxopyrrol-1-yl)-N-[2-[[2-[[(2S)-1-[[2-[[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]hexanamide

MC-GGFG-DX8951 (MC-GGFG-DX8951) is a drug-linker conjugate for ADC· MC-GGFG-DX8951 is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker· MC-GGFG-DX8951 shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC)

ChemicalCAS1600418-29-8MW946.97FormulaC49H51FN8O11
CAS number
1600418-29-8
Molecular weight
946.97
Formula
C49H51FN8O11
Solubility
DMSO： 100 mg/mL (105·60 mM)
InChIKey
XEKFDUNPKACYAY-SODISJPWSA-N
Catalogue number
GC39309
Brand
GLPBIO
Computed properties PubChem CID 118567450 · XLogP 0.3 · TPSA 263 Ų · H-bond donors 6
XLogP
0.3
TPSA
263 Ų
H-bond donors
6
H-bond acceptors
13
Rotatable bonds
18
Heavy atoms
69

SMILES CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)CNC(=O)[C@H](CC7=CC=CC=C7)NC(=O)CNC(=O)CNC(=O)CCCCCN8C(=O)C=CC8=O)O

Computed descriptors from PubChem (CID 118567450), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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