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Chemical structure of LCH-7749944

GC39209

LCH-7749944

Also known as 2-N-(3-methoxyphenyl)-4-N-(oxolan-2-ylmethyl)quinazoline-2,4-diamine

LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14·93 μM· LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis

ChemicalCAS796888-12-5MW350.41FormulaC20H22N4O2
CAS number
796888-12-5
Molecular weight
350.41
Formula
C20H22N4O2
Solubility
DMSO： 250 mg/mL (713·45 mM)
InChIKey
FBWZAFQEOKNGQL-UHFFFAOYSA-N
Catalogue number
GC39209
Brand
GLPBIO
Computed properties PubChem CID 2951910 · XLogP 4.1 · TPSA 68.3 Ų · H-bond donors 2
XLogP
4.1
TPSA
68.3 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
26

SMILES COC1=CC=CC(=C1)NC2=NC3=CC=CC=C3C(=N2)NCC4CCCO4

Computed descriptors from PubChem (CID 2951910), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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