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Chemical structure of iRucaparib-AP6

GC39191

iRucaparib-AP6

Also known as 2-(2,6-dioxopiperidin-3-yl)-4-[2-[2-[2-[2-[2-[2-[2-[[4-(6-fluoro-9-oxo-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-2-yl)phenyl]methyl-methylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]isoindole-1,3-dione

iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using thePROTAC approach· iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1

ChemicalCAS2410557-00-3MW886.96FormulaC46H55FN6O11
CAS number
2410557-00-3
Molecular weight
886.96
Formula
C46H55FN6O11
Solubility
DMSO： 50 mg/mL (56·37 mM)
InChIKey
YHMDCINUVWULST-UHFFFAOYSA-N
Catalogue number
GC39191
Brand
GLPBIO
Computed properties PubChem CID 138857977 · XLogP 2.5 · TPSA 199 Ų · H-bond donors 4
XLogP
2.5
TPSA
199 Ų
H-bond donors
4
H-bond acceptors
14
Rotatable bonds
26
Heavy atoms
64

SMILES CN(CCOCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O)CC4=CC=C(C=C4)C5=C6CCNC(=O)C7=C6C(=CC(=C7)F)N5

Computed descriptors from PubChem (CID 138857977), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.