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Chemical structure of SR-4835

GC39175

SR-4835

Also known as N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-ylpurin-6-amine

SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4·9 nM)· SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death

ChemicalCAS2387704-62-1MW499.36FormulaC21H20Cl2N10O
CAS number
2387704-62-1
Molecular weight
499.36
Formula
C21H20Cl2N10O
Solubility
DMSO： 5 mg/mL (10·01 mM; ultrasonic and warming and heat to 60°C)
InChIKey
FSELUFUYNUNZKD-UHFFFAOYSA-N
Catalogue number
GC39175
Brand
GLPBIO
Computed properties PubChem CID 139600338 · XLogP 2.8 · TPSA 115 Ų · H-bond donors 2
XLogP
2.8
TPSA
115 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
34

SMILES CN1C=C(C=N1)N2C=NC3=C(N=C(N=C32)N4CCOCC4)NCC5=NC6=CC(=C(C=C6N5)Cl)Cl

Computed descriptors from PubChem (CID 139600338), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.