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Chemical structure of TCH-165

GC39166

TCH-165

Also known as ethyl (4R,5R)-3-benzyl-4-[4-(benzylamino)phenyl]-2-(4-methoxyphenyl)-5-phenyl-4H-imidazole-5-carboxylate

TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation

ChemicalCAS1446350-60-2MW595.73FormulaC39H37N3O3
CAS number
1446350-60-2
Molecular weight
595.73
Formula
C39H37N3O3
Solubility
DMSO: 250 mg/mL (419·65 mM)
InChIKey
XXDLWRCUPASJGY-AEGYFVCZSA-N
Catalogue number
GC39166
Brand
GLPBIO
Computed properties PubChem CID 71762768 · XLogP 7.5 · TPSA 63.2 Ų · H-bond donors 1
XLogP
7.5
TPSA
63.2 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
12
Heavy atoms
45

SMILES CCOC(=O)[C@]1([C@H](N(C(=N1)C2=CC=C(C=C2)OC)CC3=CC=CC=C3)C4=CC=C(C=C4)NCC5=CC=CC=C5)C6=CC=CC=C6

Computed descriptors from PubChem (CID 71762768), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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