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Chemical structure of D-I03

GC39149

D-I03

Also known as 1-[2-(diethylamino)ethyl]-3-[2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl]thiourea

D-I03 is a selective RAD52 inhibitor with a Kd of 25·8 ?M· D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 ?M and 8 ?M, respectively· D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin

ChemicalCAS688342-78-1MW428.64FormulaC23H36N6S
CAS number
688342-78-1
Molecular weight
428.64
Formula
C23H36N6S
Solubility
DMSO： ≥ 100 mg/mL (233·30 mM)
InChIKey
UXDGHRWOHOPKIL-UHFFFAOYSA-N
Catalogue number
GC39149
Brand
GLPBIO
Computed properties PubChem CID 24761372 · XLogP 3.6 · TPSA 78.8 Ų · H-bond donors 2
XLogP
3.6
TPSA
78.8 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
8
Heavy atoms
30

SMILES CCN1CCN(CC1)C2=NC3=C(C=C(C=C3)NC(=S)NCCN(CC)CC)C(=C2)C

Computed descriptors from PubChem (CID 24761372), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.