GC38932
NDI-091143
Also known as methyl 3-chloro-5-[(2,4-difluoro-5-phenylphenyl)sulfamoyl]-4-hydroxybenzoate
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2·1 nM (ADP-Glo assay), a Ki of 7·0 nM and a Kd of 2·2 nM· NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate
ChemicalCAS2375840-87-0MW453.84FormulaC20H14ClF2NO5S
- CAS number
- 2375840-87-0
- Molecular weight
- 453.84
- Formula
- C20H14ClF2NO5S
- Solubility
- DMSO： 125 mg/mL (275·43 mM)
- InChIKey
- YSTSHUWHIDBZAK-UHFFFAOYSA-N
- Catalogue number
- GC38932
- Brand
- GLPBIO
Computed properties PubChem CID 137796782 · XLogP 4.9 · TPSA 101 Ų · H-bond donors 2
- XLogP
- 4.9
- TPSA
- 101 Ų
- H-bond donors
- 2
- H-bond acceptors
- 8
- Rotatable bonds
- 6
- Heavy atoms
- 30
SMILES COC(=O)C1=CC(=C(C(=C1)Cl)O)S(=O)(=O)NC2=C(C=C(C(=C2)C3=CC=CC=C3)F)F
Computed descriptors from PubChem (CID 137796782), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il