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Chemical structure of RIPK1-IN-4

GC38841

RIPK1-IN-4

Also known as 1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea

RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase

ChemicalCAS1481641-08-0MW401.46FormulaC23H23N5O2
CAS number
1481641-08-0
Molecular weight
401.46
Formula
C23H23N5O2
Solubility
DMSO： 250 mg/mL (622·73 mM)
InChIKey
SLRYMOUSQMDJPH-UHFFFAOYSA-N
Catalogue number
GC38841
Brand
GLPBIO
Computed properties PubChem CID 71816195 · XLogP 4.4 · TPSA 106 Ų · H-bond donors 3
XLogP
4.4
TPSA
106 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
30

SMILES CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CC=CC4=C3C=CN=C4N

Computed descriptors from PubChem (CID 71816195), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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