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Chemical structure of JWG-071

GC38804

JWG-071

Also known as 11-butan-2-yl-2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5-methylpyrimido[4,5-b][1,4]benzodiazepin-6-one

JWG-071 is the first reported kinase-selective chemical probe for ERK5· JWG-071 improves ERK5 activity and BRD4 selectivity· JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology

ChemicalCAS2250323-50-1MW612.76FormulaC34H44N8O3
CAS number
2250323-50-1
Molecular weight
612.76
Formula
C34H44N8O3
Solubility
Soluble in DMSO
InChIKey
ACWOMSOYIIVIRV-UHFFFAOYSA-N
Catalogue number
GC38804
Brand
GLPBIO
Computed properties PubChem CID 131842089 · XLogP 4.3 · TPSA 97.4 Ų · H-bond donors 1
XLogP
4.3
TPSA
97.4 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
45

SMILES CCC(C)N1C2=CC=CC=C2C(=O)N(C3=CN=C(N=C31)NC4=C(C=C(C=C4)C(=O)N5CCC(CC5)N6CCN(CC6)C)OC)C

Computed descriptors from PubChem (CID 131842089), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.