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Chemical structure of ERRα antagonist-1

GC38777

ERRα antagonist-1

Also known as 3-(4,5-dihydro-1,3-thiazol-2-yl)-N-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)-1,3-thiazolidin-2-imine

ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist· ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively· ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1

ChemicalCAS1072145-33-5MW377.53FormulaC21H19N3S2
CAS number
1072145-33-5
Molecular weight
377.53
Formula
C21H19N3S2
Solubility
DMSO： 7·14 mg/mL (18·91 mM)
InChIKey
OWLQZFQCFCNPKV-UHFFFAOYSA-N
Catalogue number
GC38777
Brand
GLPBIO
Computed properties PubChem CID 25015530 · XLogP 4.8 · TPSA 78.6 Ų · H-bond donors 0
XLogP
4.8
TPSA
78.6 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
26

SMILES C1CSC(=N1)N2CCSC2=NC3C4=CC=CC=C4C=CC5=CC=CC=C35

Computed descriptors from PubChem (CID 25015530), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.