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Chemical structure of Kuwanon H

GC38510

Kuwanon H

Also known as 8-[(1S,5R,6S)-6-[2,4-dihydroxy-3-(3-methylbut-2-enyl)benzoyl]-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methylbut-2-enyl)chromen-4-one

eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor· eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex)

ChemicalCAS76472-87-2MW760.82FormulaC45H44O11
CAS number
76472-87-2
Molecular weight
760.82
Formula
C45H44O11
Solubility
Soluble in DMSO
InChIKey
DKBPTKFKCCNXNH-QXGWMLRCSA-N
Catalogue number
GC38510
Brand
GLPBIO
Computed properties PubChem CID 5281668 · XLogP 9.2 · TPSA 205 Ų · H-bond donors 8
XLogP
9.2
TPSA
205 Ų
H-bond donors
8
H-bond acceptors
11
Rotatable bonds
9
Heavy atoms
56

SMILES CC1=C[C@@H]([C@H]([C@@H](C1)C2=C(C=C(C=C2)O)O)C(=O)C3=C(C(=C(C=C3)O)CC=C(C)C)O)C4=C(C=C(C5=C4OC(=C(C5=O)CC=C(C)C)C6=C(C=C(C=C6)O)O)O)O

Computed descriptors from PubChem (CID 5281668), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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