Loading...
Chemical structure of DM3-SMe

GC38355

DM3-SMe

Also known as [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl-[4-(methyldisulfanyl)pentanoyl]amino]propanoate

DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond· DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0·0011 nM

ChemicalCAS796073-70-6MW812.43FormulaC38H54ClN3O10S2
CAS number
796073-70-6
Molecular weight
812.43
Formula
C38H54ClN3O10S2
Solubility
Soluble in DMSO
InChIKey
YCOIJPSIDUQDNN-UQJMXLCASA-N
Catalogue number
GC38355
Brand
GLPBIO
Computed properties PubChem CID 139600327 · XLogP 3.4 · TPSA 207 Ų · H-bond donors 2
XLogP
3.4
TPSA
207 Ų
H-bond donors
2
H-bond acceptors
12
Rotatable bonds
11
Heavy atoms
54

SMILES C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCC(C)SSC)C)\C)OC)(NC(=O)O2)O

Computed descriptors from PubChem (CID 139600327), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.