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Chemical structure of Tazemetostat hydrobromide

GC38163

Tazemetostat hydrobromide

Also known as N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide;hydrobromide

Tazemetostat hydrobromide (EPZ-6438 hydrobromide) is a potent, selective and orally available EZH2 inhibitor· Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2·5 nM· Tazemetostat hydrobromide inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively· Tazemetostat hydrobromide inhibits Rat EZH2 with an IC50 of 4 nM· Tazemetostat hydrobromide also inhibits EZH1 with an IC50 of 392 nM

ChemicalCAS1467052-75-0MW653.65FormulaC34H45BrN4O4
CAS number
1467052-75-0
Molecular weight
653.65
Formula
C34H45BrN4O4
Solubility
DMSO： 100 mg/mL (152·99 mM)
InChIKey
UQRICAQPWZSJNF-UHFFFAOYSA-N
Catalogue number
GC38163
Brand
GLPBIO
Computed properties PubChem CID 71761627 · TPSA 83.1 Ų · H-bond donors 3 · H-bond acceptors 6
TPSA
83.1 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
9
Heavy atoms
43

SMILES CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5.Br

Computed descriptors from PubChem (CID 71761627), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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