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Chemical structure of Danicopan

GC38162

Danicopan

Also known as (2S,4R)-1-[2-[3-acetyl-5-(2-methylpyrimidin-5-yl)indazol-1-yl]acetyl]-N-(6-bromo-2-pyridinyl)-4-fluoropyrrolidine-2-carboxamide

Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0·54 nM

ChemicalCAS1903768-17-1MW580.41FormulaC26H23BrFN7O3
CAS number
1903768-17-1
Molecular weight
580.41
Formula
C26H23BrFN7O3
Solubility
DMSO： 260 mg/mL (447·96 mM)
InChIKey
PIBARDGJJAGJAJ-NQIIRXRSSA-N
Catalogue number
GC38162
Brand
GLPBIO
Computed properties PubChem CID 118323590 · XLogP 3.3 · TPSA 123 Ų · H-bond donors 1
XLogP
3.3
TPSA
123 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
38

SMILES CC1=NC=C(C=N1)C2=CC3=C(C=C2)N(N=C3C(=O)C)CC(=O)N4C[C@@H](C[C@H]4C(=O)NC5=NC(=CC=C5)Br)F

Computed descriptors from PubChem (CID 118323590), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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