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Chemical structure of FAK ligand-Linker Conjugate 1

GC38127

FAK ligand-Linker Conjugate 1

Also known as 3-[2-[4-[[4-[[3-[methyl(methylsulfonyl)amino]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenoxy]ethoxy]propanoic acid

FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP)· FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation

ChemicalCAS2307461-45-4MW583.58FormulaC25H28F3N5O6S
CAS number
2307461-45-4
Molecular weight
583.58
Formula
C25H28F3N5O6S
Solubility
Soluble in DMSO
InChIKey
OSVHAJNGZCDBGV-UHFFFAOYSA-N
Catalogue number
GC38127
Brand
GLPBIO
Computed properties PubChem CID 139290997 · XLogP 3.2 · TPSA 151 Ų · H-bond donors 3
XLogP
3.2
TPSA
151 Ų
H-bond donors
3
H-bond acceptors
14
Rotatable bonds
14
Heavy atoms
40

SMILES CN(C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC=C(C=C3)OCCOCCC(=O)O)S(=O)(=O)C

Computed descriptors from PubChem (CID 139290997), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
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