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Chemical structure of Shield-1

GC38060

Shield-1

Also known as [(1R)-3-(3,4-dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate

Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins

ChemicalCAS914805-33-7MW748.9FormulaC42H56N2O10
CAS number
914805-33-7
Molecular weight
748.9
Formula
C42H56N2O10
Solubility
DMSO： ≥ 250 mg/mL (333·82 mM)
InChIKey
NMFHJNAPXOMSRX-PUPDPRJKSA-N
Catalogue number
GC38060
Brand
GLPBIO
Computed properties PubChem CID 44455162 · XLogP 6.4 · TPSA 114 Ų · H-bond donors 0
XLogP
6.4
TPSA
114 Ų
H-bond donors
0
H-bond acceptors
11
Rotatable bonds
19
Heavy atoms
54

SMILES CC[C@@H](C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCC[C@H]2C(=O)O[C@H](CCC3=CC(=C(C=C3)OC)OC)C4=CC(=CC=C4)OCCN5CCOCC5

Computed descriptors from PubChem (CID 44455162), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.