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Chemical structure of Uprosertib hydrochloride

GC37859

Uprosertib hydrochloride

Also known as N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-1-methylpyrazol-5-yl)furan-2-carboxamide;hydrochloride

Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively

ChemicalCAS1047635-80-2MW465.71FormulaC18H17Cl3F2N4O2
CAS number
1047635-80-2
Molecular weight
465.71
Formula
C18H17Cl3F2N4O2
Solubility
Soluble in DMSO
InChIKey
LAPFKCIDRPWAFU-PPHPATTJSA-N
Catalogue number
GC37859
Brand
GLPBIO
Computed properties PubChem CID 73330428 · TPSA 86.1 Ų · H-bond donors 3 · H-bond acceptors 6
TPSA
86.1 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
29

SMILES CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)N[C@@H](CC3=CC(=C(C=C3)F)F)CN)Cl.Cl

Computed descriptors from PubChem (CID 73330428), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
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