Loading...
Chemical structure of TGR-1202 hydrochloride

GC37854

TGR-1202 hydrochloride

Also listed as Umbralisib hydrochloride

Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22·2 nM and 6·0 μM, respectively· Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells· Umbralisib hydrochloride can be used for haematological malignancies reseach

ChemicalCAS1532533-78-0MW608.01FormulaC31H25ClF3N5O3
CAS number
1532533-78-0
Molecular weight
608.01
Formula
C31H25ClF3N5O3
Solubility
DMSO： ≥ 150 mg/mL (246·71 mM); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
QGVUVMVWYWMZIR-NTISSMGPSA-N
Catalogue number
GC37854
Brand
GLPBIO
Computed properties PubChem CID 90030289 · TPSA 105 Ų · H-bond donors 2 · H-bond acceptors 10
TPSA
105 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
43

SMILES C[C@@H](C1=C(C(=O)C2=C(O1)C=CC(=C2)F)C3=CC(=CC=C3)F)N4C5=NC=NC(=C5C(=N4)C6=CC(=C(C=C6)OC(C)C)F)N.Cl

Computed descriptors from PubChem (CID 90030289), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.