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Chemical structure of Tafamidis meglumine

GC37720

Tafamidis meglumine

Also known as 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol

Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2·7-3·2 μM

ChemicalCAS951395-08-7MW503.33FormulaC21H24Cl2N2O8
CAS number
951395-08-7
Molecular weight
503.33
Formula
C21H24Cl2N2O8
Solubility
DMSO： 12·5 mg/mL (24·83 mM); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
DQJDBUPLRMRBAB-WZTVWXICSA-N
Catalogue number
GC37720
Brand
GLPBIO
Computed properties PubChem CID 24970412 · TPSA 177 Ų · H-bond donors 7 · H-bond acceptors 10
TPSA
177 Ų
H-bond donors
7
H-bond acceptors
10
Rotatable bonds
8
Heavy atoms
33

SMILES CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl

Computed descriptors from PubChem (CID 24970412), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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