GC37709
SY-1365
Also known as N-[(1S,3R)-3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-1-methylcyclohexyl]-5-[[(E)-4-(dimethylamino)but-2-enoyl]amino]pyridine-2-carboxamide
SY-1365 (SY-1365) is a potent and first-in-class selective CDK7 inhibitor, with a Ki of 17·4 nM· SY-1365 exhibits anti-proliferative and apoptotic effects in solid tumor cell lines· SY-1365 possesses anti-tumor activity in hematological and multiple aggressive solid tumors
ChemicalCAS1816989-16-8MW587.12FormulaC31H35ClN8O2
- CAS number
- 1816989-16-8
- Molecular weight
- 587.12
- Formula
- C31H35ClN8O2
- Solubility
- DMSO： 125 mg/mL (212·90 mM)
- InChIKey
- SCJNYBYSTCRPAO-LXBQGUBHSA-N
- Catalogue number
- GC37709
- Brand
- GLPBIO
Computed properties PubChem CID 118426108 · XLogP 4.2 · TPSA 128 Ų · H-bond donors 4
- XLogP
- 4.2
- TPSA
- 128 Ų
- H-bond donors
- 4
- H-bond acceptors
- 7
- Rotatable bonds
- 9
- Heavy atoms
- 42
SMILES C[C@@]1(CCC[C@H](C1)NC2=NC=C(C(=N2)C3=CNC4=CC=CC=C43)Cl)NC(=O)C5=NC=C(C=C5)NC(=O)/C=C/CN(C)C
Computed descriptors from PubChem (CID 118426108), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il