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Chemical structure of Spebrutinib besylate

GC37672

Spebrutinib besylate

Also known as benzenesulfonic acid;N-[3-[[5-fluoro-2-[4-(2-methoxyethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC50＜0·5 nM, Kinact/Ki=7·69×104 M-1s-1s) in biochemical assays

ChemicalCAS1360053-81-1MW581.62FormulaC28H28FN5O6S
CAS number
1360053-81-1
Molecular weight
581.62
Formula
C28H28FN5O6S
Solubility
Soluble in DMSO
InChIKey
ABSXPNGWJFAPRT-UHFFFAOYSA-N
Catalogue number
GC37672
Brand
GLPBIO
Computed properties PubChem CID 74892828 · TPSA 160 Ų · H-bond donors 4 · H-bond acceptors 11
TPSA
160 Ų
H-bond donors
4
H-bond acceptors
11
Rotatable bonds
11
Heavy atoms
41

SMILES COCCOC1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)F.C1=CC=C(C=C1)S(=O)(=O)O

Computed descriptors from PubChem (CID 74892828), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.