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Chemical structure of Silvestrol aglycone

GC37638

Silvestrol aglycone

Also known as methyl (1R,2R,3S,3aR,8bS)-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate

Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively· Anti-cancer activity

ChemicalCAS960365-65-5MW478.49FormulaC27H26O8
CAS number
960365-65-5
Molecular weight
478.49
Formula
C27H26O8
Solubility
DMSO： ≥ 106 mg/mL (221·53 mM)
InChIKey
HYLOONIBWUNKDH-PXIJUOARSA-N
Catalogue number
GC37638
Brand
GLPBIO
Computed properties PubChem CID 24178739 · XLogP 2.9 · TPSA 115 Ų · H-bond donors 3
XLogP
2.9
TPSA
115 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
35

SMILES COC1=CC=C(C=C1)[C@]23[C@@H]([C@H]([C@H]([C@]2(C4=C(O3)C=C(C=C4OC)O)O)O)C(=O)OC)C5=CC=CC=C5

Computed descriptors from PubChem (CID 24178739), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.