GC37603
SC144 hydrochloride
Also known as N'-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide;hydrochloride
SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor· SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes· SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling· SC144 hydrochloride induces apoptosis in human ovarian cancer cells
- CAS number
- 917497-70-2
- Molecular weight
- 358.76
- Formula
- C16H12ClFN6O
- Solubility
- DMSO： 10 mg/mL (27·87 mM)
- InChIKey
- LKFGGXYXFIICED-UHFFFAOYSA-N
- Catalogue number
- GC37603
- Brand
- GLPBIO
Computed properties PubChem CID 66921431 · TPSA 84.2 Ų · H-bond donors 3 · H-bond acceptors 6
- TPSA
- 84.2 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Rotatable bonds
- 3
- Heavy atoms
- 25
SMILES C1=CN2C3=C(C=C(C=C3)F)N=C(C2=C1)NNC(=O)C4=NC=CN=C4.Cl
Computed descriptors from PubChem (CID 66921431), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il