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Chemical structure of Ripretinib

GC37538

Ripretinib

Also known as 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea

Ripretinib (DCC-2618) is an orally bioavailable, selective KIT and PDGFRA switch-control inhibitor· Ripretinib (DCC-2618) targets and binds to both wild-type and mutant forms of KIT and PDGFRA specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms· Ripretinib (DCC-2618) also inhibits multiple other kinase targets, such as FLT3 and KDR (or VEGFR-2)· DCC-2618 exerts antineoplastic effect and induces apoptosis

ChemicalCAS1442472-39-0MW510.36FormulaC24H21BrFN5O2
CAS number
1442472-39-0
Molecular weight
510.36
Formula
C24H21BrFN5O2
Solubility
DMSO： 45 mg/mL (88·17 mM)
InChIKey
CEFJVGZHQAGLHS-UHFFFAOYSA-N
Catalogue number
GC37538
Brand
GLPBIO
Computed properties PubChem CID 71584930 · XLogP 4.1 · TPSA 86.4 Ų · H-bond donors 3
XLogP
4.1
TPSA
86.4 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
33

SMILES CCN1C2=CC(=NC=C2C=C(C1=O)C3=CC(=C(C=C3Br)F)NC(=O)NC4=CC=CC=C4)NC

Computed descriptors from PubChem (CID 71584930), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.