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Chemical structure of Quarfloxin

GC37051

Quarfloxin

Also known as 15-fluoro-N-[2-[(2S)-1-methylpyrrolidin-2-yl]ethyl]-18-oxo-14-(3-pyrazin-2-ylpyrrolidin-1-yl)-12-oxa-1-azapentacyclo[11.7.1.02,11.04,9.017,21]henicosa-2,4,6,8,10,13(21),14,16,19-nonaene-19-carboxamide

Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells· Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template

ChemicalCAS865311-47-3MW604.67FormulaC35H33FN6O3
CAS number
865311-47-3
Molecular weight
604.67
Formula
C35H33FN6O3
Solubility
Soluble in DMSO
InChIKey
WOQIDNWTQOYDLF-CGAIIQECSA-N
Catalogue number
GC37051
Brand
GLPBIO
Computed properties PubChem CID 11635763 · XLogP 5.1 · TPSA 90.9 Ų · H-bond donors 1
XLogP
5.1
TPSA
90.9 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
6
Heavy atoms
45

SMILES CN1CCC[C@H]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O

Computed descriptors from PubChem (CID 11635763), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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