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Chemical structure of PT2977

GC37034

PT2977

Also known as 3-[[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-methylsulfonyl-2,3-dihydro-1H-inden-4-yl]oxy]-5-fluorobenzonitrile

PT2977 (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM· PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile· PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC)

ChemicalCAS1672668-24-4MW383.34FormulaC17H12F3NO4S
CAS number
1672668-24-4
Molecular weight
383.34
Formula
C17H12F3NO4S
Solubility
DMSO： 50 mg/mL (130·43 mM)
InChIKey
LOMMPXLFBTZENJ-ZACQAIPSSA-N
Catalogue number
GC37034
Brand
GLPBIO
Computed properties PubChem CID 117947097 · XLogP 2 · TPSA 95.8 Ų · H-bond donors 1
XLogP
2
TPSA
95.8 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
3
Heavy atoms
26

SMILES CS(=O)(=O)C1=C2[C@@H]([C@@H]([C@@H](C2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)F)F)O

Computed descriptors from PubChem (CID 117947097), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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