Loading...
Chemical structure of Mutated EGFR-IN-1

GC36666

Mutated EGFR-IN-1

Also known as 1-N-[2-(dimethylamino)ethyl]-5-methoxy-1-N-methyl-4-N-[4-(1-methylindol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant

ChemicalCAS1421372-66-8MW445.56FormulaC25H31N7O
CAS number
1421372-66-8
Molecular weight
445.56
Formula
C25H31N7O
Solubility
DMSO： ≥ 75 mg/mL (168·33 mM)
InChIKey
HTNTZPBKKCORTP-UHFFFAOYSA-N
Catalogue number
GC36666
Brand
GLPBIO
Computed properties PubChem CID 78358313 · XLogP 3.3 · TPSA 84.5 Ų · H-bond donors 2
XLogP
3.3
TPSA
84.5 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
8
Heavy atoms
33

SMILES CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)N)N(C)CCN(C)C)OC

Computed descriptors from PubChem (CID 78358313), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.