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Chemical structure of Mardepodect hydrochloride

GC36541

Mardepodect hydrochloride

Also known as 2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline;hydrochloride

Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0·37 nM, with >1000-fold selectivity over other PDEs· Mardepodect hydrochloride can cross the blood-brain barrier

ChemicalCAS2070014-78-5MW428.91FormulaC25H21ClN4O
CAS number
2070014-78-5
Molecular weight
428.91
Formula
C25H21ClN4O
Solubility
DMSO: 25 mg/mL (58·29 mM)
InChIKey
BDHTXAXWOXYUDG-UHFFFAOYSA-N
Catalogue number
GC36541
Brand
GLPBIO
Computed properties PubChem CID 122412737 · TPSA 52.8 Ų · H-bond donors 1 · H-bond acceptors 4
TPSA
52.8 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
5
Heavy atoms
31

SMILES CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)C5=CC=NC=C5.Cl

Computed descriptors from PubChem (CID 122412737), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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