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Chemical structure of Kushenol A

GC36402

Kushenol A

Also known as (2S)-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one

Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent· Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1·1 μM and 0·4 μM, respectively· Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6·8 μM) and β-amylase· Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging

ChemicalCAS99217-63-7MW408.49FormulaC25H28O5
CAS number
99217-63-7
Molecular weight
408.49
Formula
C25H28O5
Solubility
Soluble in DMSO
InChIKey
OGBMVWVBHWHRGD-MWTRTKDXSA-N
Catalogue number
GC36402
Brand
GLPBIO
Computed properties PubChem CID 44563121 · XLogP 6.1 · TPSA 87 Ų · H-bond donors 3
XLogP
6.1
TPSA
87 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
30

SMILES CC(=CC[C@H](CC1=C2C(=C(C=C1O)O)C(=O)C[C@H](O2)C3=CC=CC=C3O)C(=C)C)C

Computed descriptors from PubChem (CID 44563121), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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