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Chemical structure of GW791343 dihydrochloride

GC36202

GW791343 dihydrochloride

Also known as 2-(3,4-difluoroanilino)-N-[2-methyl-5-(piperazin-1-ylmethyl)phenyl]acetamide;dihydrochloride

GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6·9-7·2

ChemicalCAS1019779-04-4MW447.35FormulaC20H26Cl2F2N4O
CAS number
1019779-04-4
Molecular weight
447.35
Formula
C20H26Cl2F2N4O
Solubility
Water： 100 mg/mL (223·54 mM); DMSO： 20 mg/mL (44·71 mM)
InChIKey
IYJPZTBIYHPSKF-UHFFFAOYSA-N
Catalogue number
GC36202
Brand
GLPBIO
Computed properties PubChem CID 71576670 · TPSA 56.4 Ų · H-bond donors 5 · H-bond acceptors 6
TPSA
56.4 Ų
H-bond donors
5
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
29

SMILES CC1=C(C=C(C=C1)CN2CCNCC2)NC(=O)CNC3=CC(=C(C=C3)F)F.Cl.Cl

Computed descriptors from PubChem (CID 71576670), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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