Loading...
Chemical structure of Glucose-conjugated MGMT inhibitor

GC36153

Glucose-conjugated MGMT inhibitor

Also known as (2R,3R,4S,5S,6R)-2-[8-[2-amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]octoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

Glucose-conjugated MGMT inhibitor is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells

ChemicalCAS382607-78-5MW616.53FormulaC24H34BrN5O7S
CAS number
382607-78-5
Molecular weight
616.53
Formula
C24H34BrN5O7S
Solubility
DMSO： 100 mg/mL (162·20 mM)
InChIKey
WAAZBVOGWRQLMB-PUIBNRJISA-N
Catalogue number
GC36153
Brand
GLPBIO
Computed properties PubChem CID 10438805 · XLogP 2.1 · TPSA 206 Ų · H-bond donors 5
XLogP
2.1
TPSA
206 Ų
H-bond donors
5
H-bond acceptors
12
Rotatable bonds
14
Heavy atoms
38

SMILES C1=C(SC=C1Br)COC2=NC(=NC3=C2N=CN3CCCCCCCCO[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)N

Computed descriptors from PubChem (CID 10438805), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.