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Chemical structure of Domatinostat

GC35893

Domatinostat

Also known as (E)-N-(2-aminophenyl)-3-[1-[4-(1-methylpyrazol-4-yl)phenyl]sulfonylpyrrol-3-yl]prop-2-enamide

Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1·20 μM, 1·12 μM, and 0·57 μM for HDAC1, HDAC2, and HDAC3, respectively· It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1)

ChemicalCAS910462-43-0MW447.51FormulaC23H21N5O3S
CAS number
910462-43-0
Molecular weight
447.51
Formula
C23H21N5O3S
Solubility
DMSO： ≥ 58 mg/mL (129·61 mM)
InChIKey
PRXXYMVLYKJITB-IZZDOVSWSA-N
Catalogue number
GC35893
Brand
GLPBIO
Computed properties PubChem CID 15985904 · XLogP 2.4 · TPSA 120 Ų · H-bond donors 2
XLogP
2.4
TPSA
120 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
32

SMILES CN1C=C(C=N1)C2=CC=C(C=C2)S(=O)(=O)N3C=CC(=C3)/C=C/C(=O)NC4=CC=CC=C4N

Computed descriptors from PubChem (CID 15985904), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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