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Chemical structure of DK419

GC35873

DK419

Also known as 6-chloro-2-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazole-4-carboxamide

DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0·19 μM· DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK

ChemicalCAS2102672-22-8MW407.7FormulaC16H8ClF6N3O
CAS number
2102672-22-8
Molecular weight
407.7
Formula
C16H8ClF6N3O
Solubility
DMSO： 83·33 mg/mL (204·39 mM)
InChIKey
MWNNIGRGNSXNEA-UHFFFAOYSA-N
Catalogue number
GC35873
Brand
GLPBIO
Computed properties PubChem CID 44536362 · XLogP 4.8 · TPSA 57.8 Ų · H-bond donors 2
XLogP
4.8
TPSA
57.8 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
2
Heavy atoms
27

SMILES C1=CC(=CC=C1C(F)(F)F)NC(=O)C2=C3C(=CC(=C2)Cl)NC(=N3)C(F)(F)F

Computed descriptors from PubChem (CID 44536362), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.