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Chemical structure of Cucurbitacin D

GC35757

Cucurbitacin D

Also known as (2S,8S,9R,10R,13R,14S,16R,17R)-17-[(E,2R)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthrene-3,11-dione

Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23· Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response· Anti-cancer activity

ChemicalCAS3877-86-9MW516.67FormulaC30H44O7
CAS number
3877-86-9
Molecular weight
516.67
Formula
C30H44O7
Solubility
Soluble in DMSO
InChIKey
SRPHMISUTWFFKJ-QJNWWGCFSA-N
Catalogue number
GC35757
Brand
GLPBIO
Computed properties PubChem CID 5281318 · XLogP 2.1 · TPSA 132 Ų · H-bond donors 4
XLogP
2.1
TPSA
132 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
37

SMILES C[C@@]12C[C@H]([C@@H]([C@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C[C@@H](C(=O)C4(C)C)O)C)C)[C@](C)(C(=O)/C=C/C(C)(C)O)O)O

Computed descriptors from PubChem (CID 5281318), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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