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Chemical structure of CP-10

GC35739

CP-10

Also known as 4-[2-[2-[4-[[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]piperazin-1-yl]methyl]triazol-1-yl]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2·1 nM)· It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6

ChemicalCAS2366268-80-4MW871.94FormulaC44H49N13O7
CAS number
2366268-80-4
Molecular weight
871.94
Formula
C44H49N13O7
Solubility
DMSO： 200 mg/mL (229·37 mM)
InChIKey
PACRWHUPEPCFHX-UHFFFAOYSA-N
Catalogue number
GC35739
Brand
GLPBIO
Computed properties PubChem CID 138911323 · XLogP 1.8 · TPSA 230 Ų · H-bond donors 3
XLogP
1.8
TPSA
230 Ų
H-bond donors
3
H-bond acceptors
16
Rotatable bonds
15
Heavy atoms
64

SMILES CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)CC5=CN(N=N5)CCOCCNC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O)C9CCCC9)C(=O)C

Computed descriptors from PubChem (CID 138911323), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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