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Chemical structure of Alectinib Hydrochloride

GC35280

Alectinib Hydrochloride

Also known as 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;hydrochloride

Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1·9 nM and a Kd value of 2·4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3·5 nM, respectively· Alectinib demonstrates effective central nervous system (CNS) penetration

ChemicalCAS1256589-74-8MW519.08FormulaC30H35ClN4O2
CAS number
1256589-74-8
Molecular weight
519.08
Formula
C30H35ClN4O2
Solubility
DMSO： 6 mg/mL (11·56 mM and warming)
InChIKey
GYABBVHSRIHYJR-UHFFFAOYSA-N
Catalogue number
GC35280
Brand
GLPBIO
Computed properties PubChem CID 53239799 · TPSA 72.4 Ų · H-bond donors 2 · H-bond acceptors 5
TPSA
72.4 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
37

SMILES CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C.Cl

Computed descriptors from PubChem (CID 53239799), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
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