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Chemical structure of MW-150 dihydrochloride dihydrate

GC34918

MW-150 dihydrochloride dihydrate

Also known as 6-(4-methylpiperazin-1-yl)-3-naphthalen-2-yl-4-pyridin-4-ylpyridazine;dihydrate;dihydrochloride

MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM

ChemicalCAS1661020-92-3MW490.43FormulaC24H29Cl2N5O2
CAS number
1661020-92-3
Molecular weight
490.43
Formula
C24H29Cl2N5O2
Solubility
DMSO : 20·83 mg/mL (42·47 mM)
InChIKey
URBRIDWUCWBFOU-UHFFFAOYSA-N
Catalogue number
GC34918
Brand
GLPBIO
Computed properties PubChem CID 131747633 · TPSA 47.2 Ų · H-bond donors 4 · H-bond acceptors 7
TPSA
47.2 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
3
Heavy atoms
33

SMILES CN1CCN(CC1)C2=NN=C(C(=C2)C3=CC=NC=C3)C4=CC5=CC=CC=C5C=C4.O.O.Cl.Cl

Computed descriptors from PubChem (CID 131747633), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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