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Chemical structure of BRM/BRG1 ATP Inhibitor-1

GC34891

BRM/BRG1 ATP Inhibitor-1

Also known as 1-[3-(difluoromethyl)-1,2-thiazol-5-yl]-3-[2-fluoro-5-(hydroxymethyl)-4-pyridinyl]urea

BRM/BRG1 ATP Inhibitor-1 (compound 14) is an orally active allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0·005 ?M· BRM/BRG1 ATP Inhibitor-1 has anticancer activity

ChemicalCAS2270879-17-7MW318.27FormulaC11H9F3N4O2S
CAS number
2270879-17-7
Molecular weight
318.27
Formula
C11H9F3N4O2S
Solubility
DMSO： 250 mg/mL (785·50 mM)
InChIKey
CKYCAIAVJIFWPE-UHFFFAOYSA-N
Catalogue number
GC34891
Brand
GLPBIO
Computed properties PubChem CID 137701967 · XLogP 1.6 · TPSA 115 Ų · H-bond donors 3
XLogP
1.6
TPSA
115 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
21

SMILES C1=C(C(=CN=C1F)CO)NC(=O)NC2=CC(=NS2)C(F)F

Computed descriptors from PubChem (CID 137701967), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.