Loading...
Chemical structure of TC-I 2014

GC34833

TC-I 2014

Also known as 3-[4-(trifluoromethyl)-6-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene

TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0·8 nM, 3·0 nM and 4·4 nM for canine, human and rat channels respectively

ChemicalCAS1221349-53-6MW467.41FormulaC23H19F6N3O
CAS number
1221349-53-6
Molecular weight
467.41
Formula
C23H19F6N3O
Solubility
Soluble in DMSO
InChIKey
VSMFCZZEKTVDHM-UHFFFAOYSA-N
Catalogue number
GC34833
Brand
GLPBIO
Computed properties PubChem CID 135883253 · XLogP 6.7 · TPSA 50.3 Ų · H-bond donors 1
XLogP
6.7
TPSA
50.3 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
2
Heavy atoms
33

SMILES C1CCC2(CC1)CC(=NO2)C3=NC4=C(C=C(C=C4N3)C5=CC=CC=C5C(F)(F)F)C(F)(F)F

Computed descriptors from PubChem (CID 135883253), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.